Article
Connecting autophagy to senescence in pathophysiology.
Current opinion in cell biology - 1 Apr 2010
Young Andrew Rj, Narita Masashi
Abstract excerpt
Cellular senescence is an extremely stable form of cell cycle arrest activated in response to stress. Autophagy, a lysosome-dependent cellular catabolic process, can also be triggered by cellular stresses. Both senescence and autophagy have been implicated in a similar range of pathophysiologies, including cancer, aging and age-related symptoms. Senescence is a heterogeneous phenotype that is composed of multiple...
Topics
- Animals
- Autophagy
- Cellular Senescence
- Disease
- Feedback, Physiological
- Humans
- Intracellular Signaling Peptides and Proteins
- Phenotype
- Protein Serine-Threonine Kinases
- TOR Serine-Threonine Kinases
- beta-Galactosidase