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Article

P2Y6 contributes to ovalbumin-induced allergic asthma by enhancing mast cell function in mice.

Oncotarget - 20 Sept 2016

Shi Jue-Ping, Wang Shao-Ying, Chen Li-Li, Zhang Xiao-Yu, Zhao Yi-Han, Du Bing, Jiang Wen-Zheng, Qian Min, Ren Hua

Abstract excerpt

Extracelluar nucleotides have been identified as regulatory factors in asthmatic pathogenesis by activating purinergic receptors. This research aimed to investigate the function of the purinergic receptor P2Y6 in mediating airway inflammation in allergic asthma. Wild-type (WT) and P2Y6-deficient mice were stimulated with ovalbumin (OVA) to construct asthmatic mouse models. Overexpression of P2Y6 and uridine...

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Source

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Identifiers

PMID: 27590515
DOI: 10.18632/oncotarget.11758
PMCID: PMC5308625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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