Association of DNA Methyltransferase 3B Promotor Polymorphism With Childhood Chronic Immune Thrombocytopenia.

doi:10.1093/labmed/lmw040

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Article

Association of DNA Methyltransferase 3B Promotor Polymorphism With Childhood Chronic Immune Thrombocytopenia.

Laboratory medicine - 1 Nov 2016

Gouda Heba M, Kamel Nermine M, Meshaal Safa S

Abstract excerpt

BACKGROUND: DNA methylation is an epigenetic process that refers to chromatin-based mechanisms in the regulation of gene expression without DNA alternation. It is mediated by DNA methyltransferases (DNMTs). The DNA methyltransferase 3B (DNMT3B) gene contains a C-to-T single nucleotide polymorphism (SNP; rs2424913) in the Promotor region, 149 base pairs from the transcription start site, which is reported to...

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PMID: 27590349
DOI: 10.1093/labmed/lmw040

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