Article
Single nucleotide polymorphism in DNMT3B promoter and the risk for idiopathic thrombocytopenic purpura in Chinese population.
Journal of clinical immunology - 1 Sept 2008
Chen Zhenping, Zhou Zeping, Chen Xiaoli, Xu Jianhui, Liu Aijuan, Du Weiting, Gu Dongsheng, Ge Jing, Guo Zhenxing, Wang Xiaoyan, Dong Xunwei, Ren Qian, Yang Renchi
Abstract excerpt
OBJECTIVE: Epigenetic changes in gene expression, including DNA methylation and histone modifications, might contribute to autoimmunity. DNA methylation is mediated by a family of DNA methyltransferases. Polymorphisms of the DNA methyltransferase 3B (DNMT3B) gene may influence DNMT3B activity on...
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