Article
DNMT3B 579G>T promoter polymorphism and the risk for idiopathic thrombocytopenic purpura in a Chinese population.
Acta haematologica - 1 Jan 2009
Zhao Haifeng, Du Weiting, Gu Dongsheng, Wang Donghai, Xue Feng, Ge Jing, Sui Tao, Yang Renchi
Abstract excerpt
Epigenetics may influence the expression of numerous genes, which might contribute to autoimmune diseases. DNA methylation is mediated by DNA methyltransferases, especially DNA methyltransferase 3B (DNMT3B). Polymorphisms of the DNMT3B gene may influence DNMT3B activity on DNA methylation and increase the susceptibility to several diseases. The current study investigated the association between DNMT3B 579G>T and...
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