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DNA Methylation and Primary Immune Thrombocytopenia

1 Jan 2013

Abstract excerpt

DNA methylation is a heritable, stable, and also reversible way of DNA modification; it can regulate gene expression without changing the nucleotide sequences. Because it takes part in regulation of immune responses, the loss of methylation homeostasis in immune cells will result in autoimmune disease by inducing aberrant gene expression. Primary immune thrombocytopenia (ITP) is an acquired autoimmune disease...

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PMID: 23664508
DOI: 10.1053/j.seminhematol.2013.03.022

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