DNA methyltransferase 3B gene promoter and interleukin-1 receptor antagonist polymorphisms in childhood immune thrombocytopenia.

doi:10.1155/2012/352059

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Article

DNA methyltransferase 3B gene promoter and interleukin-1 receptor antagonist polymorphisms in childhood immune thrombocytopenia.

Clinical & developmental immunology - 1 Jan 2012

Pesmatzoglou Margarita, Lourou Marilena, Goulielmos George N, Stiakaki Eftichia

Abstract excerpt

Primary immune thrombocytopenia (ITP) is one of the most common blood diseases as well as the commonest acquired bleeding disorder in childhood. Although the etiology of ITP is unclear, in the pathogenesis of the disease, both environmental and genetic factors including polymorphisms of TNF-a, IL-10, and IL-4 genes have been suggested to be involved. In this study, we investigated the rs2424913 single-nucleotide...

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PMID: 23049596
DOI: 10.1155/2012/352059
PMCID: PMC3461273

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