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Article

KCNQ variants and pain modulation: a missense variant in Kv7.3 contributes to pain resilience

1 Jan 2021

Abstract excerpt

Abstract There is a pressing need for understanding of factors that confer resilience to pain. Gain-of-function mutations in sodium channel Nav1.7 produce hyperexcitability of dorsal root ganglion neurons underlying inherited erythromelalgia, a human genetic model of neuropathic pain. While most individuals with erythromelalgia experience excruciating pain, occasional outliers report more moderate pain. These...

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PMID: 34557669
DOI: 10.1093/braincomms/fcab212

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