Article

Neutrophils from Alzheimer’s Disease mice fail to phagocytose debris and show altered release of immune modulators with age

2025-04-25

Abstract excerpt

Recent reports show that neutrophil activity plays a role in the cognitive decline associated with Alzheimer’s Disease (AD). There is evidence of altered functions in neutrophils isolated from AD patients. Whether these altered functions are inherent to the AD disease state is unknown. The goal of this study was to determine if neutrophil functions are altered in AD mice and if these changes occur only after sympt...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1da3b3d8-e582-5ee2-acf8-e9183eb8a9b7
DOI: 10.1101/2025.04.21.649766

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 9 closest

Neutrophils from Alzheimer’s Disease mice fail to phagocytose debris and show altered release of immune modulators with ageDOI 10.1101/2025.04.21.649766Read

The emerging role of neutrophils in neurodegeneration.Semantic proximity Read

The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide.Semantic proximity Read

An increased neutrophil–lymphocyte ratio in Alzheimer's disease is a function of age and is weakly correlated with neocortical amyloid accumulationSemantic proximity Read

Neutrophil Extracellular Traps Mediate <i>In Vitro</i> and <i>In Vivo</i> Degradation of α-Synuclein Amyloid FibrilsSemantic proximity Read

Leptomeningeal Cells Induce Synaptic Failure via Cathepsin B-mediated IL-1ß Production after Porphyromonas Gingivalis InfectionSemantic proximity Read

Circadian Modulation of Neutrophil Function Determines Collateral Perfusion and Outcome After Ischemic StrokeSemantic proximity Read

The development of giant phagocytes in long-term neutrophil cultures.Semantic proximity Read

Amyloid‐beta 1‐40 is associated with alterations in NG2+ pericyte population ex vivo and in vitroSemantic proximity Read

MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation.Semantic proximity Read