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Article

Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population.

BMC ophthalmology - 1 Sept 2016

Al-Shahrani Hamoud, Al-Dabbagh Najwa, Al-Dohayan Nourah, Arfin Misbahul, Al-Asmari Mohammad, Rizvi Sadaf, Al-Asmari Abdulrahman

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate metabolism is involved in DNA synthesis, DNA repair and DNA methylation. The functional polymorphism of MTHFR gene, C677T has been shown to impact various diseases and implicated as a risk factor for the development of various neurodegenerative disorders including glaucoma. METHODS: We investigated MTHFR C677T genotypes and...

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Identifiers

PMID: 27585654
DOI: 10.1186/s12886-016-0337-7
PMCID: PMC5009653

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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