Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylenetetrahydrofolatereductase (MTHFR) 677C>T polymorphism and open angle glaucoma.

Molecular vision - 17 Apr 2006

Mossbock Georg, Weger Martin, Faschinger Christoph, Steinbrugger Iris, Temmel Werner, Schmut Otto, Renner Wilfried, Hufnagel Clemens, Stanger Olaf

Abstract excerpt

PURPOSE: Increased plasma homocysteine levels have been found in patients with primary open angle glaucoma (POAG) and glaucoma secondary to pseudoexfoliation syndrome (PEXG). A common polymorphism of the methylenetetrahydrofolatereductase (MTHFR 677C>T) leads to moderately elevated plasma homocysteine levels particularly under conditions of impaired folate status. It was the aim of this study to investigate a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytosine

Share to Exfoliation Syndrome

Share to Glaucoma, Open-Angle

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Odds Ratio

Share to Thymine

Source

Identifiers

PMID: 16636653

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylenetetrahydrofolatereductase (MTHFR) 677C>T polymorphism and open angle glaucoma.PMID 16636653Read ↗

C677T variant in the methylentetrahydrofolate reductase gene is a genetic risk factor for primary open-angle glaucoma.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase 677 C-T and homocysteine levels in Turkish patients with pseudoexfoliation.Semantic proximity Read ↗

Plasma Homocysteine, MTHFR Gene Mutation, and Open-angle GlaucomaSemantic proximity Read ↗

Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma.Semantic proximity Read ↗

Homocysteine, B vitamins, methylenetetrahydrofolate reductase gene, and risk of primary open-angle glaucoma: a meta-analysis.Semantic proximity Read ↗

Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population.Semantic proximity Read ↗

Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis.Semantic proximity Read ↗

Association between MTHFR C677T polymorphism and primary open-angle glaucoma: a meta-analysis.Semantic proximity Read ↗

Lack of association between the C677T single nucleotide polymorphism of the MTHFR gene and glaucoma in Iranian patients.Semantic proximity Read ↗

Lack of association of polymorphisms in homocysteine metabolism genes with pseudoexfoliation syndrome and glaucoma.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene polymorphisms c.677C/T and c.1298A/C are not associated with open angle glaucoma.Semantic proximity Read ↗

C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with primary closed angle glaucoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.