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Article

Methylenetetrahydrofolatereductase (MTHFR) 677C>T polymorphism and open angle glaucoma.

Molecular vision - 17 Apr 2006

Mossbock Georg, Weger Martin, Faschinger Christoph, Steinbrugger Iris, Temmel Werner, Schmut Otto, Renner Wilfried, Hufnagel Clemens, Stanger Olaf

Abstract excerpt

PURPOSE: Increased plasma homocysteine levels have been found in patients with primary open angle glaucoma (POAG) and glaucoma secondary to pseudoexfoliation syndrome (PEXG). A common polymorphism of the methylenetetrahydrofolatereductase (MTHFR 677C>T) leads to moderately elevated plasma homocys...

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Source

Identifiers

PMID: 16636653

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16636653-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Methylenetetrahydrofolatereductase (MTHFR) 677C>T polymorphism and open angle glaucoma.PMID 16636653Read ↗

C677T variant in the methylentetrahydrofolate reductase gene is a genetic risk factor for primary open-angle glaucoma.Semantic proximity Read ↗

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Plasma Homocysteine, MTHFR Gene Mutation, and Open-angle GlaucomaSemantic proximity Read ↗

Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma.Semantic proximity Read ↗

Homocysteine, B vitamins, methylenetetrahydrofolate reductase gene, and risk of primary open-angle glaucoma: a meta-analysis.Semantic proximity Read ↗

Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population.Semantic proximity Read ↗

Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis.Semantic proximity Read ↗

Association between MTHFR C677T polymorphism and primary open-angle glaucoma: a meta-analysis.Semantic proximity Read ↗

Lack of association between the C677T single nucleotide polymorphism of the MTHFR gene and glaucoma in Iranian patients.Semantic proximity Read ↗

Lack of association of polymorphisms in homocysteine metabolism genes with pseudoexfoliation syndrome and glaucoma.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene polymorphisms c.677C/T and c.1298A/C are not associated with open angle glaucoma.Semantic proximity Read ↗

C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with primary closed angle glaucoma.Semantic proximity Read ↗

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