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Article

MTHFR C677T predisposes to POAG but not to PACG in a North Indian population: a case control study.

PloS one - 1 Jan 2014

Gupta Shashank, Bhaskar Pradeep Kumar, Bhardwaj Ritu, Chandra Abhishek, Chaudhry Vidya Nair, Chaudhry Prashaant, Ali Akhtar, Mukherjee Ashim, Mutsuddi Mousumi

Abstract excerpt

Hyperhomocysteinemia induced by the C677T genetic variant in MTHFR (methylenetetrahydrofolate reductase) has been implicated in neuronal cell death of retinal ganglion cells (RGC), which is a characteristic feature of glaucoma. However, association of MTHFR C677T with glaucoma has been controversial because of inconsistent results across association studies. Association between MTHFR C677T and glaucoma has not...

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Identifiers

PMID: 25054348
DOI: 10.1371/journal.pone.0103063
PMCID: PMC4108368

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MTHFR C677T predisposes to POAG but not to PACG in a North Indian population: a case control study.PMID 25054348Read ↗

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