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Article

C677T variant in the methylentetrahydrofolate reductase gene is a genetic risk factor for primary open-angle glaucoma.

American journal of ophthalmology - 1 Apr 2005

Jünemann Anselm G M, von Ahsen Nico, Reulbach Udo, Roedl Johannes, Bönsch Dominikus, Kornhuber Johannes, Kruse Friedrich E, Bleich Stefan

Abstract excerpt

PURPOSE: To estimate the prevalence of C677T single nucleotide polymorphism in the 5,10-methylentetrahydrofolate reductase (MTHFR) gene in primary open-angle glaucoma (POAG) and pseudoexfoliation open-angle glaucoma (PEXG). DESIGN: Case-control study METHODS: MTHFR was assessed in 147 patients (76 POAG, 71 PEXG) and 71 control subjects with cataract. Associations of genotypes were assessed by Armitage's trend...

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Source

Identifiers

PMID: 15808177
DOI: 10.1016/j.ajo.2004.09.081

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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