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Article

Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts.

The Biochemical journal - 1 Nov 2016

Zhong Xiaowei, Sun Bo, Vallmitjana Alexander, Mi Tao, Guo Wenting, Ni Mingke, Wang Ruiwu, Guo Ang, Duff Henry J, Gillis Anne M, Song Long-Sheng, Hove-Madsen Leif, Benitez Raul, Chen S R Wayne

Abstract excerpt

Beat-to-beat alternations in the amplitude of the cytosolic Ca2+ transient (Ca2+ alternans) are thought to be the primary cause of cardiac alternans that can lead to cardiac arrhythmias and sudden death. Despite its important role in arrhythmogenesis, the mechanism underlying Ca2+ alternans remains poorly understood. Here, we investigated the role of cardiac ryanodine receptor (RyR2), the major Ca2+ release...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isoproterenol

Share to Myocytes, Cardiac

Share to Polymorphic Catecholaminergic Ventricular Tachycardia

Share to Ryanodine Receptor Calcium Release Channel

Share to Sarcoplasmic Reticulum

Share to Tachycardia, Ventricular

Source

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Identifiers

PMID: 27582498
DOI: 10.1042/BCJ20160606
PMCID: PMC5522810

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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