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Article

Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jun 2013

Brunello Lucia, Slabaugh Jessica L, Radwanski Przemyslaw B, Ho Hsiang-Ting, Belevych Andriy E, Lou Qing, Chen Haiyan, Napolitano Carlo, Lodola Francesco, Priori Silvia G, Fedorov Vadim V, Volpe Pompeo, Fill Michael, Janssen Paul M L, Györke Sándor

Abstract excerpt

Dysregulated intracellular Ca(2+) signaling is implicated in a variety of cardiac arrhythmias, including catecholaminergic polymorphic ventricular tachycardia. Spontaneous diastolic Ca(2+) release (DCR) can induce arrhythmogenic plasma membrane depolarizations, although the mechanism responsible for DCR synchronization among adjacent myocytes required for ectopic activity remains unclear. We investigated the...

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Share to Calcium Signaling
Share to Calsequestrin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Heart Ventricles

Share to Polymorphic Catecholaminergic Ventricular Tachycardia

Share to Ryanodine Receptor Calcium Release Channel

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Share to Tachycardia, Ventricular

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Identifiers

PMID: 23733959
DOI: 10.1073/pnas.1300052110
PMCID: PMC3690898

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