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Article

Molecular, Subcellular, and Arrhythmogenic Mechanisms in Genetic RyR2 Disease.

Biomolecules - 26 Jul 2022

Fowler Ewan Douglas, Zissimopoulos Spyros

Abstract excerpt

The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple functional domains with specific roles, and four of these RyR2 protomers are required to form the quaternary structure that comprises the functional channel. Numerous mutations in the gene encoding RyR2 protein have been identified and many are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35892340
DOI: 10.3390/biom12081030
PMCID: PMC9394283

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