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Histone loaders CAF1 and HIRA restrict Epstein-Barr virus B-cell lytic reactivation

2020-04-30

Abstract excerpt

<h4>ABSTRACT</h4> Epstein-Barr virus (EBV) infects 95% of adults worldwide and causes infectious mononucleosis. EBV is associated with endemic Burkitt lymphoma, Hodgkin lymphoma, post-transplant lymphomas, nasopharyngeal and gastric carcinomas. In these cancers and in most infected B-cells, EBV maintains a state of latency, where nearly 80 lytic cycle antigens are epigenetically suppressed. To gain insights into...

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Literature Corpus work
e115ff03-6702-5144-9474-0f0eee3bc3a0
DOI
10.1101/2020.04.28.067371
Open publication

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Histone loaders CAF1 and HIRA restrict Epstein-Barr virus B-cell lytic reactivationDOI 10.1101/2020.04.28.067371
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