Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shank3 Is Part of a Zinc-Sensitive Signaling System That Regulates Excitatory Synaptic Strength.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Aug 2016

Arons Magali H, Lee Kevin, Thynne Charlotte J, Kim Sally A, Schob Claudia, Kindler Stefan, Montgomery Johanna M, Garner Craig C

Abstract excerpt

UNLABELLED: Shank3 is a multidomain scaffold protein localized to the postsynaptic density of excitatory synapses. Functional studies in vivo and in vitro support the concept that Shank3 is critical for synaptic plasticity and the trans-synaptic coupling between the reliability of presynaptic neurotransmitter release and postsynaptic responsiveness. However, how Shank3 regulates synaptic strength remains unclear....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chelating Agents
Share to Chlorides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dendritic Spines

Share to Excitatory Postsynaptic Potentials

Share to Receptors, AMPA

Share to Synapses

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 27581454
DOI: 10.1523/JNEUROSCI.0116-16.2016
PMCID: PMC5005722

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shank3 Is Part of a Zinc-Sensitive Signaling System That Regulates Excitatory Synaptic Strength.PMID 27581454Read ↗

Shank synaptic scaffold proteins: keys to understanding the pathogenesis of autism and other synaptic disorders.Semantic proximity Read ↗

A role for synaptic zinc in ProSAP/Shank PSD scaffold malformation in autism spectrum disorders.Semantic proximity Read ↗

SHANK proteins: roles at the synapse and in autism spectrum disorder.Semantic proximity Read ↗

SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism.Semantic proximity Read ↗

S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis.Semantic proximity Read ↗

Adult restoration of Shank3 expression rescues selective autistic-like phenotypes.Semantic proximity Read ↗

The emerging role of SHANK genes in neuropsychiatric disorders.Semantic proximity Read ↗

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3Semantic proximity Read ↗

Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders.Semantic proximity Read ↗

Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits.Semantic proximity Read ↗

Association of SHANK Family with Neuropsychiatric Disorders: An Update on Genetic and Animal Model Discoveries.Semantic proximity Read ↗

The Shank/ProSAP N-terminal (SPN) domain of Shank3 regulates targeting to postsynaptic sites and postsynaptic signallingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.