Article
S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis.
Translational psychiatry - 5 Nov 2021
Daini Eleonora, Hagmeyer Simone, De Benedictis Chiara A, Cristóvão Joana S, Bodria Martina, Ross Aisling M, Raab Andrea, Boeckers Tobias M, Feldmann Joerg, Gomes Cláudio M, Zoli Michele, Vilella Antonietta, Grabrucker Andreas M
Abstract excerpt
Autism Spectrum Disorders (ASD) are caused by a combination of genetic predisposition and nongenetic factors. Among the nongenetic factors, maternal immune system activation and zinc deficiency have been proposed. Intriguingly, as a genetic factor, copy-number variations in S100B, a pro-inflammatory damage-associated molecular pattern (DAMP), have been associated with ASD, and increased serum S100B has been found...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.