Article
Novel filaggrin mutation but no other loss-of-function variants found in Ethiopian patients with atopic dermatitis.
The British journal of dermatology - 1 Nov 2011
Winge M C G, Bilcha K D, Liedén A, Shibeshi D, Sandilands A, Wahlgren C-F, McLean W H I, Nordenskjöld M, Bradley M
Abstract excerpt
BACKGROUND: Filaggrin is a key protein involved in maintaining skin barrier function and hydration. Mutations in the filaggrin gene (FLG) cause ichthyosis vulgaris (IV) and are a major predisposing factor for atopic dermatitis (AD) in individuals of European and Asian descent. It has been proposed that FLG mutations are population specific and a difference in the spectra of mutations between different ancestral...
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