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Article

Genetic variation in the epidermal transglutaminase genes is not associated with atopic dermatitis.

PloS one - 1 Jan 2012

Liedén Agne, Winge Mårten C G, Sääf Annika, Kockum Ingrid, Ekelund Elisabeth, Rodriguez Elke, Fölster-Holst Regina, Franke Andre, Illig Thomas, Tengvall-Linder Maria, Baurecht Hansjörg, Weidinger Stephan, Wahlgren Carl-Fredrik, Nordenskjöld Magnus, Bradley Maria

Abstract excerpt

BACKGROUND: Atopic dermatitis (AD) is a common chronic inflammatory skin disorder where epidermal barrier dysfunction is a major factor in the pathogenesis. The identification of AD susceptibility genes related to barrier dysfunction is therefore of importance. The epidermal transglutaminases (TGM1, TGM3 and TGM5) encodes essential cross-linking enzymes in the epidermis. OBJECTIVE: To determine whether genetic...

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Source

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Identifiers

PMID: 23189155
DOI: 10.1371/journal.pone.0049694
PMCID: PMC3506648

Genes

TGM1
TGM3
TGM5
FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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