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Article

Functional molecular analysis of a circadian clock gene timeless promoter from the Drosophilid fly Chymomyza costata.

Journal of biological rhythms - 1 Dec 2010

Kobelková Alena, Bajgar Adam, Dolezel David

Abstract excerpt

The circadian transcription of the tim gene is tightly regulated by the protein complex dCLK/CYC, which directly interacts with a series of closely spaced E-box and E-box-like elements in the Drosophila timeless promoter. The tim promoter from D. melanogaster has been studied in detail both in tissue cultures and in living flies yet has never been investigated in other species. This article presents a detailed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21135156
DOI: 10.1177/0748730410385283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

Functional molecular analysis of a circadian clock gene timeless promoter from the Drosophilid fly Chymomyza costata.PMID 21135156Read ↗

dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex.Semantic proximity Read ↗

Regulation of the cycling of timeless (tim) RNA.Semantic proximity Read ↗

CRTC Potentiates Light-independent timeless Transcription to Sustain Circadian Rhythms in Drosophila.Semantic proximity Read ↗

Positional cloning and sequence analysis of the Drosophila clock gene, timeless.Semantic proximity Read ↗

Interlocked feedback loops within the Drosophila circadian oscillator.Semantic proximity Read ↗

TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo.Semantic proximity Read ↗

Clock-gated photic stimulation of timeless expression at cold temperatures and seasonal adaptation in Drosophila.Semantic proximity Read ↗

A PER/TIM/DBT interval timer for Drosophila's circadian clock.Semantic proximity Read ↗

A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization, and transcriptional repressor activity.Semantic proximity Read ↗

CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless.Semantic proximity Read ↗

A simple model of circadian rhythms based on dimerization and proteolysis of PER and TIM.Semantic proximity Read ↗

Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila.Semantic proximity Read ↗

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