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Article

Functional molecular analysis of a circadian clock gene timeless promoter from the Drosophilid fly Chymomyza costata.

Journal of biological rhythms - 1 Dec 2010

Kobelková Alena, Bajgar Adam, Dolezel David

Abstract excerpt

The circadian transcription of the tim gene is tightly regulated by the protein complex dCLK/CYC, which directly interacts with a series of closely spaced E-box and E-box-like elements in the Drosophila timeless promoter. The tim promoter from D. melanogaster has been studied in detail both in ti...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21135156
DOI: 10.1177/0748730410385283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21135156-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Functional molecular analysis of a circadian clock gene timeless promoter from the Drosophilid fly Chymomyza costata.PMID 21135156Read ↗

dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex.Semantic proximity Read ↗

Regulation of the cycling of timeless (tim) RNA.Semantic proximity Read ↗

CRTC Potentiates Light-independent timeless Transcription to Sustain Circadian Rhythms in Drosophila.Semantic proximity Read ↗

Positional cloning and sequence analysis of the Drosophila clock gene, timeless.Semantic proximity Read ↗

Interlocked feedback loops within the Drosophila circadian oscillator.Semantic proximity Read ↗

TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo.Semantic proximity Read ↗

Clock-gated photic stimulation of timeless expression at cold temperatures and seasonal adaptation in Drosophila.Semantic proximity Read ↗

A PER/TIM/DBT interval timer for Drosophila's circadian clock.Semantic proximity Read ↗

A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization, and transcriptional repressor activity.Semantic proximity Read ↗

CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless.Semantic proximity Read ↗

A simple model of circadian rhythms based on dimerization and proteolysis of PER and TIM.Semantic proximity Read ↗

Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila.Semantic proximity Read ↗

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