Article
RNA2DNAlign: nucleotide resolution allele asymmetries through quantitative assessment of RNA and DNA paired sequencing data.
Nucleic acids research - 15 Dec 2016
Movassagh Mercedeh, Alomran Nawaf, Mudvari Prakriti, Dede Merve, Dede Cem, Kowsari Kamran, Restrepo Paula, Cauley Edmund, Bahl Sonali, Li Muzi, Waterhouse Wesley, Tsaneva-Atanasova Krasimira, Edwards Nathan, Horvath Anelia
Abstract excerpt
We introduce RNA2DNAlign, a computational framework for quantitative assessment of allele counts across paired RNA and DNA sequencing datasets. RNA2DNAlign is based on quantitation of the relative abundance of variant and reference read counts, followed by binomial tests for genotype and allelic status at SNV positions between compatible sequences. RNA2DNAlign detects positions with differential allele...
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