Article
Neoplastic cellularity is associated with clinical and molecular features of high-grade serous ovarian carcinoma.
Gynecologic oncology - 1 Nov 2016
Morse Christopher B, Norquist Barbara M, Harrell Maria I, Agnew Kathy J, Gray Heidi J, Urban Renata R, Garcia Rochelle L, Goff Barbara A, Swisher Elizabeth M
Abstract excerpt
OBJECTIVE: Most molecular analyses of high-grade serous ovarian, peritoneal and fallopian tube carcinomas (HGSC) require ≥70% tumor (neoplastic) cell nuclei. We characterized the distribution of the percentage of neoplastic nuclei (PNN) in a large cohort of HGSC and correlated PNN with clinical outcomes to determine the fraction of cases outside this range and whether this cut-off introduces selection bias....
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