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Article

Endometrial carcinomas with dyshesive, eosinophilic, and vacuolated (histiocyte-like) tumor cells: a reactive-like phenotype associated with aggressive behavior.

Virchows Archiv : an international journal of pathology - 1 Mar 2023

Travaglino Antonio, Arciuolo Damiano, Raffone Antonio, Santoro Angela, Piermattei Alessia, Navarra Elena, Minucci Angelo, Mascolo Massimo, Scaglione Giulia, D'alessandris Nicoletta, Valente Michele, Inzani Frediano, Mollo Antonio, Insabato Luigi, Zannoni Gian Franco

Abstract excerpt

Herein, we present a clinicopathological and molecular analysis of four cases of endometrial carcinoma (EC) diffusely exhibiting dyshesive cells with wide eosinophilic and vacuolated cytoplasm (histiocyte-like tumor cells, HLTCs). We compared these HLTCs to similar cells found in microcystic, elongated and fragmented (MELF) pattern (n = 20) or after neoadjuvant chemotherapy (NAC) (n = 5). The four cases were...

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PMID: 36205778
DOI: 10.1007/s00428-022-03411-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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