Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic Progression of Precancerous Actinic Keratosis to Squamous Cell Carcinoma.

The Journal of investigative dermatology - 1 Mar 2022

Kim Yoon-Seob, Shin Sun, Jung Seung-Hyun, Park Young Min, Park Gyeong Sin, Lee Sug Hyung, Chung Yeun-Jun

Abstract excerpt

The mechanism underlying the progression of actinic keratosis (AK) and cutaneous squamous cell carcinoma (SCC) in situ (SCCIS) to SCC remains unclear. To investigate this, we performed regional microdissection and targeted deep sequencing in SCC (n = 10) and paired adjacent sun-damaged epidermis (SE)/AK/SCCIS (n = 13) samples to detect mutations and copy number alterations. Most (11/13) SE/AK/SCCIS tissues...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Genomics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Biology Techniques and Applications

Share to Mutation

Share to Nonmelanoma Skin Cancer Studies

Share to Plant Disease Resistance and Genetics

Share to Skin Neoplasms

Source

Identifiers

PMID: 34480890
DOI: 10.1016/j.jid.2021.07.172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic Progression of Precancerous Actinic Keratosis to Squamous Cell Carcinoma.PMID 34480890Read ↗

Targeted deep sequencing reveals genomic alterations of actinic keratosis/cutaneous squamous cell carcinoma in situ and cutaneous squamous cell carcinomaSemantic proximity Read ↗

Gene expression landscape of cutaneous squamous cell carcinoma progressionSemantic proximity Read ↗

Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma.Semantic proximity Read ↗

Single-cell sequencing highlights heterogeneity and malignant progression in actinic keratosis and cutaneous squamous cell carcinomaSemantic proximity Read ↗

Single-cell Sequencing Highlights Heterogeneity and Malignant Progression in Actinic Keratosis and Cutaneous Squamous Cell CarcinomaSemantic proximity Read ↗

Genetic evolution of keratinocytes to cutaneous squamous cell carcinomaSemantic proximity Read ↗

Gene Expression Patterns of Normal Human Skin, Actinic Keratosis, and Squamous Cell CarcinomaSemantic proximity Read ↗

Invasive squamous cell carcinomas and precursor lesions on UV-exposed epithelia demonstrate concordant genomic complexity in driver genes.Semantic proximity Read ↗

Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progressionSemantic proximity Read ↗

The Genomic Landscape of Actinic Keratosis.Semantic proximity Read ↗

Whole-Exome and Transcriptome Analysis of UV-Exposed Epidermis and Carcinoma In Situ Reveals Early Drivers of Carcinogenesis.Semantic proximity Read ↗

Gene expression landscape of cutaneous squamous cell carcinoma progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.