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Article

Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.

Journal of biomolecular screening - 1 Jun 2014

Dančík Vlado, Carrel Hyman, Bodycombe Nicole E, Seiler Kathleen Petri, Fomina-Yadlin Dina, Kubicek Stefan T, Hartwell Kimberly, Shamji Alykhan F, Wagner Bridget K, Clemons Paul A

Abstract excerpt

High-throughput screening allows rapid identification of new candidate compounds for biological probe or drug development. Here, we describe a principled method to generate "assay performance profiles" for individual compounds that can serve as a basis for similarity searches and cluster analyses. Our method overcomes three challenges associated with generating robust assay performance profiles: (1) we transform...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24464433
DOI: 10.1177/1087057113520226
PMCID: PMC5554958

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