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Article

Evaluation of polymorphisms in angiogenesis-related genes as predictive and prognostic markers for sunitinib-treated metastatic renal cell carcinoma patients.

Journal of cancer research and clinical oncology - 1 Jun 2016

Dornbusch Juana, Walter Martina, Gottschalk Andrea, Obaje Alice, Junker Kerstin, Ohlmann Carsten-Henning, Meinhardt Matthias, Zacharis Aristeidis, Zastrow Stefan, Schoffer Olaf, Grimm Marc-Oliver, Klug Stefanie J, Wirth Manfred P, Fuessel Susanne

Abstract excerpt

PURPOSE: Single nucleotide polymorphisms (SNPs) in angiogenesis-associated genes might play an important role in activity of the tyrosine kinase inhibitor sunitinib and could affect survival of cancer patients treated with this drug. The aim of this retrospective study was to elucidate the role of 10 known SNPs in VEGFA, VEGFR1, VEGFR2 and VEGFR3 as potential prognostic and predictive markers in an independent...

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Share to Angiogenesis Inhibitors
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Pathologic

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Share to Receptors, Vascular Endothelial Growth Factor

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Identifiers

PMID: 26935927
DOI: 10.1007/s00432-016-2137-0

Genes

VEGFA

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Evaluation of polymorphisms in angiogenesis-related genes as predictive and prognostic markers for sunitinib-treated metastatic renal cell carcinoma patients.PMID 26935927Read ↗

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