Sunitinib-induced hypertension in CYP3A4 rs4646437 A-allele carriers with metastatic renal cell carcinoma.

doi:10.1038/tpj.2015.100

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Article

Sunitinib-induced hypertension in CYP3A4 rs4646437 A-allele carriers with metastatic renal cell carcinoma.

The pharmacogenomics journal - 1 Jan 2017

Diekstra M H, Belaustegui A, Swen J J, Boven E, Castellano D, Gelderblom H, Mathijssen R H, García-Donas J, Rodríguez-Antona C, Rini B I, Guchelaar H-J

Abstract excerpt

The single nucleotide polymorphism (SNP) rs4646437G>A in CYP3A4 was suggested to be related to sunitinib toxicity. Our objective was to perform an in-depth investigation of the association between this SNP and sunitinib toxicity and efficacy using a large cohort of metastatic renal cell carcinoma (mRCC) patients. We collected DNA and clinical information of mRCC patients treated with sunitinib. SNP rs4646437 in...

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PMID: 26810136
DOI: 10.1038/tpj.2015.100

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