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Article

Genetic polymorphisms as predictive biomarker of survival in patients with gastrointestinal stromal tumors treated with sunitinib.

The pharmacogenomics journal - 1 Jan 2018

Kloth J S L, Verboom M C, Swen J J, van der Straaten T, Sleijfer S, Reyners A K L, Steeghs N, Gelderblom H, Guchelaar H J, Mathijssen R H J

Abstract excerpt

This study aimed to identify single-nucleotide polymorphisms (SNPs) that are associated with outcome to treatment with sunitinib in patients with advanced gastrointestinal stromal tumors (GIST). Forty-nine SNPS involved in the pharmacokinetic and pharmacodynamic pathway of sunitinib were associated with progression-free survival (PFS) and overall survival (OS) in 127 patients with advanced GIST who have been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28117434
DOI: 10.1038/tpj.2016.83

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POR

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