AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma.

doi:10.18632/oncotarget.11506

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Article

AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma.

Oncotarget - 20 Sept 2016

Conteduca Giuseppina, Fenoglio Daniela, Parodi Alessia, Battaglia Florinda, Kalli Francesca, Negrini Simone, Tardito Samuele, Ferrera Francesca, Salis Annalisa, Millo Enrico, Pasquale Giuseppe, Barra Giusi, Damonte Gianluca, Indiveri Francesco, Ferrone Soldano, Filaci Gilberto

Abstract excerpt

AIRE is involved in susceptibility to melanoma perhaps regulating T cell immunity against melanoma antigens (MA). To address this issue, AIRE and MAGEB2 expressions were measured by real time PCR in medullary thymic epithelial cells (mTECs) from two strains of C57BL/6 mice bearing either T or C allelic variant of the rs1800522 AIRE SNP. Moreover, the extent of apoptosis induced by mTECs in MAGEB2-specific T cells...

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Identifiers

PMID: 27563821
DOI: 10.18632/oncotarget.11506
PMCID: PMC5308622

Genes

AIRE
MAGEB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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