Article
The role of AIRE polymorphisms in melanoma.
Clinical immunology (Orlando, Fla.) - 1 Jul 2010
Conteduca G, Ferrera F, Pastorino L, Fenoglio D, Negrini S, Sormani M P, Indiveri F, Scarrà G Bianchi, Filaci G
Abstract excerpt
Polymorphisms of AIRE, a transcription factor that up-regulates intrathymic expression of tissue-specific antigens including melanoma-associated antigens (MAAs), may variably affect the selection of MAAs-specific thymocytes, generating T-cell repertoires protecting or predisposing individuals to melanoma. We found that AIRE single nucleotide polymorphisms (SNPs) rs1055311, rs1800520 and rs1800522 were...
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