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MELOE-1 is a new antigen overexpressed in melanomas and involved in adoptive T cell transfer efficiency

20 Oct 2008

Abstract excerpt

A cytotoxic T lymphocyte (CTL) clone was derived from a tumor-infiltrating lymphocyte (TIL) population infused to a melanoma patient who remained relapse free for 10 yr after this adoptive transfer. This clone recognized all melanoma cell lines tested and, to a lower extent, melanocytes, in the context of human histocompatibility leukocyte antigen A2 (HLA-A2), but it did not recognize other tumor cell types. The...

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PMID: 18936238
DOI: 10.1084/jem.20081356

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