Article
Autoimmune alleles at the major histocompatibility locus modify melanoma susceptibility.
American journal of human genetics - 6 Jul 2023
Talwar James V, Laub David, Pagadala Meghana S, Castro Andrea, Lewis McKenna, Luebeck Georg E, Gorman Bryan R, Pan Cuiping, Dong Frederick N, Markianos Kyriacos, Teerlink Craig C, Lynch Julie, Hauger Richard, Pyarajan Saiju, Tsao Philip S, Morris Gerald P, Salem Rany M, Thompson Wesley K, Curtius Kit, Zanetti Maurizio, Carter Hannah
Abstract excerpt
Autoimmunity and cancer represent two different aspects of immune dysfunction. Autoimmunity is characterized by breakdowns in immune self-tolerance, while impaired immune surveillance can allow for tumorigenesis. The class I major histocompatibility complex (MHC-I), which displays derivatives of the cellular peptidome for immune surveillance by CD8+ T cells, serves as a common genetic link between these...
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