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Article

The AIRE -230Y Polymorphism Affects AIRE Transcriptional Activity: Potential Influence on AIRE Function in the Thymus.

PloS one - 1 Jan 2015

Lovewell Thomas R J, McDonagh Andrew J, Messenger Andrew G, Azzouz Mimoun, Tazi-Ahnini Rachid

Abstract excerpt

BACKGROUND: The autoimmune regulator (AIRE) is expressed in the thymus, particularly in thymic medullary epithelial cells (mTECs), and is required for the ectopic expression of a diverse range of peripheral tissue antigens by mTECs, facilitating their ability to perform negative selection of auto-reactive immature T-cells. The expression profile of peripheral tissue antigens is affected not only by AIRE...

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Share to AIRE Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25978041
DOI: 10.1371/journal.pone.0127476
PMCID: PMC4433237

Genes

AIRE

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