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Article

Inactivation of TRP53, PTEN, RB1, and/or CDH1 in the ovarian surface epithelium induces ovarian cancer transformation and metastasis.

Biology of reproduction - 24 Apr 2020

Shi Mingxin, Whorton Allison E, Sekulovski Nikola, Paquet Marilène, MacLean James A, Song Yurong, Van Dyke Terry, Hayashi Kanako

Abstract excerpt

Ovarian cancer (OvCa) remains the most common cause of death from gynecological malignancies. Genetically engineered mouse models have been used to study initiation, origin, progression, and/or mechanisms of OvCa. Based on the clinical features of OvCa, we examined a quadruple combination of pathway perturbations including PTEN, TRP53, RB1, and/or CDH1. To characterize the cancer-promoting events in the ovarian...

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Identifiers

PMID: 31930396
DOI: 10.1093/biolre/ioaa008
PMCID: PMC7305658

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