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Low levels of IGFBP7 expression in high-grade serous ovarian carcinoma is associated with patient outcome

16 Mar 2015

Abstract excerpt

BACKGROUND: Insulin-like growth factor binding protein 7 (IGFBP7) has been suggested to act as a tumour suppressor gene in various human cancers, yet its role in epithelial ovarian cancer (EOC) has not yet been investigated. We previously observed that IGFBP7 was one of several genes found significantly upregulated in an EOC cell line model rendered non-tumourigenic as consequence of genetic manipulation. The aim...

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Share to Growth Hormone and Insulin-like Growth Factors
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PMID: 25886299
DOI: 10.1186/s12885-015-1138-8

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