Article
pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.
Science (New York, N.Y.) - 26 Aug 2016
Guo Jianping, Chakraborty Abhishek A, Liu Pengda, Gan Wenjian, Zheng Xingnan, Inuzuka Hiroyuki, Wang Bin, Zhang Jinfang, Zhang Linli, Yuan Min, Novak Jesse, Cheng Jin Q, Toker Alex, Signoretti Sabina, Zhang Qing, Asara John M, Kaelin William G, Wei Wenyi
Abstract excerpt
Activation of the serine-threonine kinase Akt promotes the survival and proliferation of various cancers. Hypoxia promotes the resistance of tumor cells to specific therapies. We therefore explored a possible link between hypoxia and Akt activity. We found that Akt was prolyl-hydroxylated by the oxygen-dependent hydroxylase EglN1. The von Hippel-Lindau protein (pVHL) bound directly to hydroxylated Akt and...
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