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Article

Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.

Molecular cell - 6 Aug 2020

Lee Sang Bae, Ko Aram, Oh Young Taek, Shi Peiguo, D'Angelo Fulvio, Frangaj Brulinda, Koller Antonius, Chen Emily I, Cardozo Timothy, Iavarone Antonio, Lasorella Anna

Abstract excerpt

Activation of dual-specificity tyrosine-phosphorylation-regulated kinases 1A and 1B (DYRK1A and DYRK1B) requires prolyl hydroxylation by PHD1 prolyl hydroxylase. Prolyl hydroxylation of DYRK1 initiates a cascade of events leading to the release of molecular constraints on von Hippel-Lindau (VHL) ubiquitin ligase tumor suppressor function. However, the proline residue of DYRK1 targeted by hydroxylation and the...

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Identifiers

PMID: 32640193
DOI: 10.1016/j.molcel.2020.06.021
PMCID: PMC7849370

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