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Article

New cancer targets emerging from studies of the Von Hippel-Lindau tumor suppressor protein.

Annals of the New York Academy of Sciences - 1 Oct 2010

Kaelin William G

Abstract excerpt

Inactivation of the von Hippel-Lindau tumor suppressor protein (pVHL) causes the most common form of kidney cancer. pVHL is part of a complex that polyubiquitinates the alpha subunit of the heterodimeric transcription factor HIF. In the presence of oxygen, HIF1α is prolyl hydroxylated by EglN1 (also called PHD2); this modification recruits pVHL, which then targets HIF1α for proteasomal degradation. In hypoxic or...

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Identifiers

PMID: 20973793
DOI: 10.1111/j.1749-6632.2010.05781.x
PMCID: PMC4784475

Genes

RBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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