Article
Nociceptin reduces the inflammatory immune microenvironment in a conventional murine model of airway hyperresponsiveness.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Feb 2017
Spaziano G, Sorrentino R, Matteis M, Malgieri G, Sgambato M, Russo T P, Terlizzi M, Roviezzo F, Rossi F, Pinto A, Fattorusso R, D'Agostino B
Abstract excerpt
BACKGROUND: Nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) are involved in airway hyperresponsiveness (AHR) and inflammation. However, the role of nociceptin at modulating the inflammatory immune microenvironment in asthma is still unclear. OBJECTIVE: To understand the role of N/OFQ in the regulation of a Th2-like environment, we used a conventional murine model of AHR. METHODS: Balb/c and CD1 mice were...
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