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Article

The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: a two-step, two-sample Mendelian randomisation study.

Diabetologia - 1 Nov 2017

Xu Lin, Borges Maria Carolina, Hemani Gibran, Lawlor Debbie A

Abstract excerpt

AIMS/HYPOTHESIS: The extent to which effects of BMI on CHD are mediated by glycaemic and lipid risk factors is unclear. In this study we examined the effects of these traits using genetic evidence. METHODS: We used two-sample Mendelian randomisation to determine: (1) the causal effect of BMI on CHD (60,801 case vs 123,504 control participants), type 2 diabetes (34,840 case vs 114,981 control participants),...

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Identifiers

PMID: 28889241
DOI: 10.1007/s00125-017-4396-y
PMCID: PMC6342872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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