Epidemiologic Association Between FUT2 Secretor Status and Severe Rotavirus Gastroenteritis in Children in the United States.

doi:10.1001/jamapediatrics.2015.2002

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Article

Epidemiologic Association Between FUT2 Secretor Status and Severe Rotavirus Gastroenteritis in Children in the United States.

JAMA pediatrics - 1 Nov 2015

Payne Daniel C, Currier Rebecca L, Staat Mary A, Sahni Leila C, Selvarangan Rangaraj, Halasa Natasha B, Englund Janet A, Weinberg Geoffrey A, Boom Julie A, Szilagyi Peter G, Klein Eileen J, Chappell James, Harrison Christopher J, Davidson Barbara S, Mijatovic-Rustempasic Slavica, Moffatt Mary D, McNeal Monica, Wikswo Mary, Bowen Michael D, Morrow Ardythe L, Parashar Umesh D

Abstract excerpt

IMPORTANCE: A genetic polymorphism affecting FUT2 secretor status in approximately one-quarter of humans of European descent affects the expression of histo-blood group antigens on the mucosal epithelia of human respiratory, genitourinary, and digestive tracts. These histo-blood group antigens serve as host receptor sites necessary for attachment and infection of some pathogens, including norovirus. OBJECTIVE: We...

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PMID: 26389824
DOI: 10.1001/jamapediatrics.2015.2002
PMCID: PMC4856001

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FUT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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