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Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels

5 Nov 2008

Abstract excerpt

Inheritance of the apoE4 allele (epsilon4) increases the risk of developing Alzheimer's disease; however, the mechanisms underlying this association remain elusive. Recent data suggest that inheritance of epsilon4 may lead to reduced apoE protein levels in the CNS. We therefore examined apoE protein levels in the brains, CSF and plasma of epsilon2/2, epsilon3/3, and epsilon4/4 targeted replacement mice. These...

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PMID: 18987181
DOI: 10.1523/jneurosci.1972-08.2008

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