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Article

Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs.

Nature - 1 Sept 2016

Tang Lin, Gamal El-Din Tamer M, Swanson Teresa M, Pryde David C, Scheuer Todd, Zheng Ning, Catterall William A

Abstract excerpt

Ca2+ antagonist drugs are widely used in therapy of cardiovascular disorders. Three chemical classes of drugs bind to three separate, but allosterically interacting, receptor sites on CaV1.2 channels, the most prominent voltage-gated Ca2+ (CaV) channel type in myocytes in cardiac and vascular smooth muscle. The 1,4-dihydropyridines are used primarily for treatment of hypertension and angina pectoris and are...

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Identifiers

PMID: 27556947
DOI: 10.1038/nature19102
PMCID: PMC5161592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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