Article
Opposite effects of a single IIIS5 mutation on phenylalkylamine and dihydropyridine interaction with L-type Ca2+ channels.
The Journal of biological chemistry - 31 Dec 2004
Huber Irene G, Wappl-Kornherr Edwin, Sinnegger-Brauns Martina J, Hoda Jean-Charles, Walter-Bastl Doris, Striessnig Jörg
Abstract excerpt
Replacement of L-type Ca(2+) channel alpha(1) subunit residue Thr-1066 in segment IIIS5 by a tyrosine residue conserved in the corresponding positions of non-L-type Ca(2+) channels eliminates high dihydropyridine sensitivity through a steric mechanism. To determine the effects of this mutation on phenylalkylamine interaction, we exploited the availability of Ca(v)1.2DHP(-/-) mice containing the T1066Y mutation....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.