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Article

Genetically Predicted Blood Pressure Across the Lifespan: Differential Effects of Mean and Pulse Pressure on Stroke Risk.

Hypertension (Dallas, Tex. : 1979) - 1 Sept 2020

Georgakis Marios K, Gill Dipender, Malik Rainer, Protogerou Athanase D, Webb Alastair J S, Dichgans Martin

Abstract excerpt

Hypertension is the leading risk factor for stroke. Yet, it remains unknown whether blood pressure pulsatility (pulse pressure [PP]) causally affects stroke risk independently of the steady pressure component (mean arterial pressure [MAP]). It is further unknown how the effects of MAP and PP on stroke risk vary with age and stroke cause. Using data from UK Biobank (N=408 228; 38-71 years), we selected genetic...

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Identifiers

PMID: 32623925
DOI: 10.1161/HYPERTENSIONAHA.120.15136
PMCID: PMC7418931

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