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Article

Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p53 target.

Oncotarget - 20 Sept 2016

Sasaki Yasushi, Tamura Miyuki, Takeda Kousuke, Ogi Kazuhiro, Nakagaki Takafumi, Koyama Ryota, Idogawa Masashi, Hiratsuka Hiroyoshi, Tokino Takashi

Abstract excerpt

The p53 tumor suppressor inhibits cell growth through the activation of both cell cycle arrest and apoptosis, which maintain genome stability and prevent cancer development. Here, we report that intercellular adhesion molecule-2 (ICAM2) is transcriptionally activated by p53. Specifically, ICAM2 is induced by the p53 family and DNA damage in a p53-dependent manner. We identified a p53 binding sequence located...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27556181
DOI: 10.18632/oncotarget.11366
PMCID: PMC5308662

Genes

ICAM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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