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CLCA2, a target of the p53 family, negatively regulates cancer cell migration and invasion

6 Dec 2012

Abstract excerpt

The tumor suppressor p53 transcriptionally regulates a number of genes that are involved in cell-cycle inhibition, apoptosis and the maintenance of genetic stability. Recent studies suggest that p53 also contributes to the regulation of cell migration and invasion. Here, we show that human chloride channel accessory-2 (CLCA2) is a target gene of the p53 family (p53, p73 and p63). CLCA2 is induced by DNA damage in...

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PMID: 22990203
DOI: 10.4161/cbt.22280

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