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Article

p53 inactivation upregulates p73 expression through E2F-1 mediated transcription.

PloS one - 1 Jan 2012

Tophkhane Chaitali, Yang Shi-He, Jiang Yunbo, Ma Zhikun, Subramaniam Dharmalingam, Anant Shrikant, Yogosawa Shingo, Sakai Toshiyuki, Liu Wan-Guo, Edgerton Susan, Thor Ann, Yang Xiaohe

Abstract excerpt

While p73 overexpression has been associated with increased apoptosis in cancer tissues, p73 overexpressing tumors appear to be of high grade malignancy. Why this putative tumor suppressor is overexpressed in cancer cells and what the function of overexpressed p73 is in breast cancers are critical questions to be addressed. By investigating the effect of p53 inactivation on p73 expression, we found that both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22952705
DOI: 10.1371/journal.pone.0043564
PMCID: PMC3431388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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